Anti-parasitic benzoxaboroles are ineffective against Theileria parva in vitro
Author: Steketee PC, Paxton E, Barrett MP, Pearce MC, Connelley TK, Morrison LJ
Year: 2023
Subject Areas: Research and Development
Keywords: Benzoxaborole, Theileria parva, drug, Apicomplexan parasites, protozoa, drug target
Comparative Sensitivity and Specificity of the 7SL sRNA Diagnostic Test for Animal Trypanosomiasis
Author: Contreras Garcia M, Walshe E, Steketee PC, Paxton E, Lopez-Vidal J, Pearce MC, Matthews KR, Ezzahra-Akki F, Evans A, Fairlie-Clark K, Matthews JB, Grey F, Morrison LJ
Year: 2022
Subject Areas: Research and Development
Keywords: Trypanosomiasis, diagnostic, sRNA, senistivity, specificity
Repositioning of a diaminothiazole series confirmed to target the cyclin-dependent kinase CRK12 for use in the treatment of African animal trypanosomiasis.
Author: Smith A, Wall RJ, Patterson S, Rowan T, Vida ER, Stojanovski L, Huggett M, Hampton SE, Thomas MG, Lopez VC, Gillingwater K, Duke J, Napier G, Peter R, Vitouley HS, Harrison JR, Milne R, Jeacock L, Baker N, Davis SH, Simeons F, Riley J, Horn D, Brun R, Zuccotto F, Witty MJ, Wyllie S, Read KD, Gilbert IH.
Year: 2022
Subject Areas: Research and Development
Parasite specific 7SL-derived small RNA is an effective target for diagnosis of active trypanosomiasis infection
Author: Chiweshe SM, Steketee PC, Jayaraman S, Paxton E, Neophytou K, Erasmus H, Labuschagne M, Cooper A, MacLeod A, Grey FE, Morrison LJ
Year: 2019
Subject Areas: Research and Development
Keywords: 7SL, Diagnosis, RNA, Trypanosomiasis, parasite
Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition
Author: Steketee PC, Dickie EA, Iremonger J, Crouch K, Paxton E
Year: 2021
Subject Areas: Research and Development
Keywords: Trypanosoma congolense, brucei, glycolyis metabolism
Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential
Author: Lauren V. Carruthers, Jane C. Munday, Godwin U. Ebiloma, Pieter Steketee, Siddharth Jayaraman, Gustavo D. Campagnaro, Marzuq A. Ungogo, Leandro Lemgruber, Anne-Marie Donachie, Tim G. Rowan, Rose Peter, Liam J. Morrison, Michael P. Barrett, Harry P. De Koning
Year: 2021
Subject Areas: Research and Development
Keywords: Diminazene, Trypanosoma congolense, Trypanosome, membrane potential, mitochondria
Prevalence of bovine trypanosomosis and assessment of trypanocidal drug resistance in tsetse infested and non-tsetse infested areas of Northwest Ethiopia
Author: Shimelis Dagnachew, BiniamTsegaye, Addissu Awukew, Meseret Tilahun, Hagos Ashenafi, Tim Rowan, Getachew Abebe, Dave J. Barry, Getachew Terefe, Bruno M. Goddeeris
Year: 2017
Subject Areas: Research and Development
Keywords: Northwest Ethiopia, Prevalence, Trypanocidal drug resistance, Trypanosomosis, Tsetse
Prioritizing smallholder animal health needs in East Africa, West Africa, and South Asia using three approaches: Literature review, expert workshops, and practitioner surveys
Author: Zoë Campbell, Paul Coleman, Andrea Guest, Peetambar Kushwaha, Thembinkosi Ramuthivheli, Tom Osebe, Brian Perry, Jeremy Salt
Year: 2021
Subject Areas: Research and Development
Keywords: Global animal health, Livestock Disease, Poor, Poverty, Prioritisation, Veterinary
Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs
Author: Federica Giordani, Daniel Paape, Isabel M. Vincent, Andrew W. Pountain, Fernando Fernández-Cortés, Eva Rico, Ning Zhang, Liam J. Morrison, Yvonne Freund, Michael J. Witty, Rosemary Peter, Darren Y. Edwards, Jonathan M. Wilkes, Justin J. J. van der Hooft, Clément Regnault, Kevin D. Read, David Horn, Mark C. Field, Michael P. Barrett
Year: 2020
Subject Areas: Research and Development
Keywords: T. brucei, T. vivax, Trypanocidal benzoxaboroles, Trypanosoma congolense
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing
Author: Daniela Begolo, Isabel M. Vincent,Federica Giordani,Ina Pöhner,Michael J. Witty,Timothy G. Rowan,Zakaria Bengaly,Kirsten Gillingwater,Yvonne Freund,Rebecca C. Wade,Michael P. Barrett,Christine Clayton
Year: 2018
Subject Areas: Research and Development
Keywords: AAT, African African Trypanosomosis, Benzoxaborole, Cattle, Protozoan, R&D, RNA, Resistance, Trypanosomiasis, Tryps ...plus 1 more
Aberrant use and poor quality of trypanocides: a risk for drug resistance in south western Ethiopia
Author: T. Tekle, G. Terefe , T. Cherenet, H. Ashenafi, K. G. Akoda, A. Teko-Agbo, J. Van Den Abbeele, G. Gari, P.-H. Clausen, A. Hoppenheit, R. C. Mattioli, R. Peter, T. Marcotty, G. Cecchi and V. Delespaux
Year: 2018
Subject Areas: Research and Development
Keywords: Diminazene, Drug quality assessment, Drug utilization practice, Ethiopia, Isometamidium, Trypanocide
Past and Ongoing Tsetse and Animal Trypanosomiasis Control Operations in Five African Countries: A Systematic Review
Author: Anne Meyer, Hannah R. Holt, Richard Selby, Javier Guitian
Year: 2016
Subject Areas: Research and Development
Keywords: Trypanosomosis, Tsetse, control programme, interviews, literature review
Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)
Author: Tsutomu Akama, Yong-Kang Zhang, Yvonne R. Freund, Pamela Berry, Joanne Lee, Eric E. Easom, Robert T. Jacobs, Jacob J. Plattner, Michael J. Witty, Rosemary Peter, Tim G. Rowan, Kirsten Gillingwater, Reto Brun, Bakela Nare, Luke Mercer, Musheng Xu, Jiangong Wang, Hao Liang
Year: 2017
Subject Areas: Research and Development
Keywords: AAT, African African Trypanosomosis, Benzoxaborole, Cattle, Lead optimisation, Protozoan, R&D, SAR, Trypanosomiasis, Trypanosomosis ...plus 2 more
AN11736, A Benzoxaborole Clinical Candidate for Treatment of T.congolense and T. vivax African Animal Trypanosomosis
Author: Yvonne R. Freund, Tsutomu Akama, Pamela Berry, Yong-Kang Zhang, Eric Easom, Robert T. Jacobs, Jacob J. Plattner, Michael Witty, Tim Rowan, Rosemary Peter
Year: 2016
Subject Areas: Research and Development
Keywords: Trypanosomosis, african animal trypanosomosis, anacor, clinical candidate, t congolense, t vivax
Ethiopia Field Study Report on Animal African Trypanosomosis
Author: Hannah Holt, Bhagyalakshmi Chengat Prakashbabu, Morgane Salines, Richard Selby, Grant Napier and Javier Guitan
Year: 2016
Subject Areas: Research and Development
Keywords: Animal African Trypanosomosis, Animal African trypanosomiasis, Cattle, Sub-Saharan Africa, Trypanosomosis, Tryps, Tsetse
Uganda Field Study Report on Animal African Trypanosomosis
Author: Morgane Salines, Richard Selby, Charles Waiswa, Hannah Holt, Grant Napier and Javier Guitian
Year: 2016
Subject Areas: Research and Development
Keywords: Animal African Trypanosomosis, Animal African trypanosomiasis, Cattle, Sub-Saharan Africa, Trypanosomosis, Tryps, Tsetse
Zambia Field Study Report on Animal African Trypanosomosis
Author: Hannah Holt, Chisoni Mumba, Morgane Salines, Richard Selby, Grant Napier and Javier Guitian
Year: 2016
Subject Areas: Research and Development
Keywords: Animal African Trypanosomosis, Animal African trypanosomiasis, Cattle, Sub-Saharan Africa, Trypanosomosis, Tryps, Tsetse
Burkina Faso Field Study Report on Animal African Trypanosomosis
Author: Morgane Salines, Hannah Holt, Richard Selby, Bhagyalakshmi Chengat Prakashbabu, Grant Napier and Javier Guitian
Year: 2016
Subject Areas: Research and Development
Keywords: Animal African Trypanosomosis, Animal African trypanosomiasis, Cattle, Sub-Saharan Africa, Trypanosomosis, Tryps, Tsetse, Vulnerability assessment
Cameroon Field Study Report on Animal African Trypanosomosis
Author: Albane Fauron, Farikou Omarou, Richard Selby, Hannah Holt, Grant Napier and Javier Guitian
Year: 2016
Subject Areas: Research and Development
Keywords: Animal African Trypanosomosis, Animal African trypanosomiasis, Cattle, Sub-Saharan Africa, Trypanosomosis, Tryps, Tsetse, Vulnerability assessment
The animal trypanosomiases and their chemotherapy: A review
Author: Federica Giordani, Liam J. Morrison, Tim G. Rowan, Harry P. De Koning and Michael P. Barrett
Year: 2016
Subject Areas: Research and Development
Keywords: Trypanosoma brucei, Trypanosoma congolense, Trypanosoma vivax, animal trypanosomiases, drug resistance, veterinary trypanocide
Proteomic Identification of Immunodiagnostic Antigens for Trypanosoma vivax Infections in Cattle and Generation of a Proof-of-Concept Lateral Flow Test Diagnostic Device
Author: Jennifer R. Fleming, Lalitha Sastry, Steven J. Wall, Lauren Sullivan, Michael A. J. Ferguson
Year: 2016
Subject Areas: Research and Development
Keywords: Animal African Trypanosomosis, Animal African trypanosomiasis, Cattle, Sub-Saharan Africa, Tryps, Tsetse, veterinary diagnosTrypanosomosis
Assessment of Animal African Trypanosomiasis vulnerability in cattle-owning communities of sub-Saharan Africa
Author: H.R. Holt, R. Selby, C. Mumba, G. B. Napier and J. Guitian
Year: 2016
Subject Areas: Research and Development
Keywords: Animal African Trypanosomosis, Animal African trypanosomiasis, Cattle, Sub-Saharan Africa, Trypanosomosis, Tryps, Tsetse, Vulnerability assessment
Identification of trans-sialidases as a common mediator of endothelial cell activation by African trypanosomes
Author: Zeinab Ammar, Nicolas Plazolles,Théo Baltz,Virginie Coustou. GALVmed and DFID acknowledged.
Year: 2013
Subject Areas: Research and Development
Keywords: Trypanosomosis
Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake
Author: Jane C. Munday, Karla E. Rojas López, Anthonius A. Eze, Vincent Delespaux, Jan Van Den Abbeele, Tim Rowan, Michael P. Barrett, Liam J. Morrison and Harry P. de Koning
Year: 2012
Subject Areas: Research and Development
Keywords: Trypanosomosis,
Community- and farmer-based management of animal African trypanosomosis in cattle
Author: Jérémy Bouyer, Fanny Bouyer, Meritxell Donadeu, Tim Rowan, Grant Napier. GALVmed and DFID acknowledged.
Year: 2013
Subject Areas: Policy and Advocacy, Research and Development
Keywords: Disease Control, Trypanosomosis, Tsetse
Erythrophagocytosis of desialylated red blood cells is responsible for anaemia during Trypanosoma vivax infection.
Author: Guegan F, Plazolles N, Baltz T, Coustou V.
Year: 2013
Subject Areas: Research and Development
Keywords: Diagnosis, Trypanosomosis
Trypanosoma vivax GM6 Antigen: A Candidate Antigen for Diagnosis of African Animal Trypanosomosis in Cattle
Author: Pillay D, Izotte J, Fikru R, Buscher P, Mucache H, Neves L, Boulange A, Seck MT, Bouyer J, Napier GB, Chevtzoff C, Costou V, Baltz T
Year: 2013
Subject Areas: Research and Development
Keywords: Diagnosis, Trypanosomosis
Development and evaluation of an ITS1 “Touchdown” PCR forassessment of drug efficacy against animal African trypanosomosis
Author: Thao Tran, Grant Napier, Tim Rowan, Claudia Cordel, Michel Labuschagne, Vincent Delespaux, Nick Van Reet, Heidi Erasmus, Annesca Joubert, Philippe Büscher
Year: 2014
Subject Areas: Research and Development
Keywords: Diagnosis, Medical Trials, Trypanosomosis
Proteomic selection of immunodiagnostic antigens for Trypanosoma congolense.
Author: Jennifer R Fleming, Lalitha Sastry, Thomas W M Crozier, Grant B Napier, Lauren Sullivan, Michael A. J. Ferguson
Year: 2014
Subject Areas: Research and Development
Keywords: Diagnosis, Trypanosomosis