Publications

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Comparative Sensitivity and Specificity of the 7SL sRNA Diagnostic Test for Animal Trypanosomiasis

Author: Contreras Garcia M, Walshe E, Steketee PC, Paxton E, Lopez-Vidal J, Pearce MC, Matthews KR, Ezzahra-Akki F, Evans A, Fairlie-Clark K, Matthews JB, Grey F, Morrison LJ

Year: 2022

Subject Areas: Research and Development

Keywords: Trypanosomiasis, diagnostic, sRNA, senistivity, specificity

Repositioning of a diaminothiazole series confirmed to target the cyclin-dependent kinase CRK12 for use in the treatment of African animal trypanosomiasis.

Author: Smith A, Wall RJ, Patterson S, Rowan T, Vida ER, Stojanovski L, Huggett M, Hampton SE, Thomas MG, Lopez VC, Gillingwater K, Duke J, Napier G, Peter R, Vitouley HS, Harrison JR, Milne R, Jeacock L, Baker N, Davis SH, Simeons F, Riley J, Horn D, Brun R, Zuccotto F, Witty MJ, Wyllie S, Read KD, Gilbert IH.

Year: 2022

Subject Areas: Research and Development

Keywords: African animal trypanosomiasis diaminothiazole

Parasite specific 7SL-derived small RNA is an effective target for diagnosis of active trypanosomiasis infection

Author: Chiweshe SM, Steketee PC, Jayaraman S, Paxton E, Neophytou K, Erasmus H, Labuschagne M, Cooper A, MacLeod A, Grey FE, Morrison LJ

Year: 2019

Subject Areas: Research and Development

Keywords: 7SL, Diagnosis, RNA, Trypanosomiasis, parasite

Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential

Author: Lauren V. Carruthers, Jane C. Munday, Godwin U. Ebiloma, Pieter Steketee, Siddharth Jayaraman, Gustavo D. Campagnaro, Marzuq A. Ungogo, Leandro Lemgruber, Anne-Marie Donachie, Tim G. Rowan, Rose Peter, Liam J. Morrison, Michael P. Barrett, Harry P. De Koning

Year: 2021

Subject Areas: Research and Development

Keywords: Diminazene, Trypanosoma congolense, Trypanosome, membrane potential, mitochondria

Prevalence of bovine trypanosomosis and assessment of trypanocidal drug resistance in tsetse infested and non-tsetse infested areas of Northwest Ethiopia

Author: Shimelis Dagnachew, BiniamTsegaye, Addissu Awukew, Meseret Tilahun, Hagos Ashenafi, Tim Rowan, Getachew Abebe, Dave J. Barry, Getachew Terefe, Bruno M. Goddeeris

Year: 2017

Subject Areas: Research and Development

Keywords: Northwest Ethiopia, Prevalence, Trypanocidal drug resistance, Trypanosomosis, Tsetse

Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs

Author: Federica Giordani, Daniel Paape, Isabel M. Vincent, Andrew W. Pountain, Fernando Fernández-Cortés, Eva Rico, Ning Zhang, Liam J. Morrison, Yvonne Freund, Michael J. Witty, Rosemary Peter, Darren Y. Edwards, Jonathan M. Wilkes, Justin J. J. van der Hooft, Clément Regnault, Kevin D. Read, David Horn, Mark C. Field, Michael P. Barrett

Year: 2020

Subject Areas: Research and Development

Keywords: T. brucei, T. vivax, Trypanocidal benzoxaboroles, Trypanosoma congolense

The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing

Author: Daniela Begolo, Isabel M. Vincent,Federica Giordani,Ina Pöhner,Michael J. Witty,Timothy G. Rowan,Zakaria Bengaly,Kirsten Gillingwater,Yvonne Freund,Rebecca C. Wade,Michael P. Barrett,Christine Clayton

Year: 2018

Subject Areas: Research and Development

Keywords: AAT, African African Trypanosomosis, Benzoxaborole, Cattle, Protozoan, R&D, RNA, Resistance, Trypanosomiasis, Tryps ...plus 1 more

Aberrant use and poor quality of trypanocides: a risk for drug resistance in south western Ethiopia

Author: T. Tekle, G. Terefe , T. Cherenet, H. Ashenafi, K. G. Akoda, A. Teko-Agbo, J. Van Den Abbeele, G. Gari, P.-H. Clausen, A. Hoppenheit, R. C. Mattioli, R. Peter, T. Marcotty, G. Cecchi and V. Delespaux

Year: 2018

Subject Areas: Research and Development

Keywords: Diminazene, Drug quality assessment, Drug utilization practice, Ethiopia, Isometamidium, Trypanocide

Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

Author: Tsutomu Akama, Yong-Kang Zhang, Yvonne R. Freund, Pamela Berry, Joanne Lee, Eric E. Easom, Robert T. Jacobs, Jacob J. Plattner, Michael J. Witty, Rosemary Peter, Tim G. Rowan, Kirsten Gillingwater, Reto Brun, Bakela Nare, Luke Mercer, Musheng Xu, Jiangong Wang, Hao Liang

Year: 2017

Subject Areas: Research and Development

Keywords: AAT, African African Trypanosomosis, Benzoxaborole, Cattle, Lead optimisation, Protozoan, R&D, SAR, Trypanosomiasis, Trypanosomosis ...plus 2 more

AN11736, A Benzoxaborole Clinical Candidate for Treatment of T.congolense and T. vivax African Animal Trypanosomosis

Author: Yvonne R. Freund, Tsutomu Akama, Pamela Berry, Yong-Kang Zhang, Eric Easom, Robert T. Jacobs, Jacob J. Plattner, Michael Witty, Tim Rowan, Rosemary Peter

Year: 2016

Subject Areas: Research and Development

Keywords: Trypanosomosis, african animal trypanosomosis, anacor, clinical candidate, t congolense, t vivax

Ethiopia Field Study Report on Animal African Trypanosomosis

Author: Hannah Holt, Bhagyalakshmi Chengat Prakashbabu, Morgane Salines, Richard Selby, Grant Napier and Javier Guitan

Year: 2016

Subject Areas: Research and Development

Keywords: Animal African Trypanosomosis, Animal African trypanosomiasis, Cattle, Sub-Saharan Africa, Trypanosomosis, Tryps, Tsetse

Uganda Field Study Report on Animal African Trypanosomosis

Author: Morgane Salines, Richard Selby, Charles Waiswa, Hannah Holt, Grant Napier and Javier Guitian

Year: 2016

Subject Areas: Research and Development

Keywords: Animal African Trypanosomosis, Animal African trypanosomiasis, Cattle, Sub-Saharan Africa, Trypanosomosis, Tryps, Tsetse

Zambia Field Study Report on Animal African Trypanosomosis

Author: Hannah Holt, Chisoni Mumba, Morgane Salines, Richard Selby, Grant Napier and Javier Guitian

Year: 2016

Subject Areas: Research and Development

Keywords: Animal African Trypanosomosis, Animal African trypanosomiasis, Cattle, Sub-Saharan Africa, Trypanosomosis, Tryps, Tsetse

Burkina Faso Field Study Report on Animal African Trypanosomosis

Author: Morgane Salines, Hannah Holt, Richard Selby, Bhagyalakshmi Chengat Prakashbabu, Grant Napier and Javier Guitian

Year: 2016

Subject Areas: Research and Development

Keywords: Animal African Trypanosomosis, Animal African trypanosomiasis, Cattle, Sub-Saharan Africa, Trypanosomosis, Tryps, Tsetse, Vulnerability assessment

The animal trypanosomiases and their chemotherapy: A review

Author: Federica Giordani, Liam J. Morrison, Tim G. Rowan, Harry P. De Koning and Michael P. Barrett

Year: 2016

Subject Areas: Research and Development

Keywords: Trypanosoma brucei, Trypanosoma congolense, Trypanosoma vivax, animal trypanosomiases, drug resistance, veterinary trypanocide

Identification of trans-sialidases as a common mediator of endothelial cell activation by African trypanosomes

Author: Zeinab Ammar, Nicolas Plazolles,Théo Baltz,Virginie Coustou. GALVmed and DFID acknowledged.

Year: 2013

Subject Areas: Research and Development

Keywords: Trypanosomosis

Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake

Author: Jane C. Munday, Karla E. Rojas López, Anthonius A. Eze, Vincent Delespaux, Jan Van Den Abbeele, Tim Rowan, Michael P. Barrett, Liam J. Morrison and Harry P. de Koning

Year: 2012

Subject Areas: Research and Development

Keywords: Trypanosomosis,

Community- and farmer-based management of animal African trypanosomosis in cattle

Author: Jérémy Bouyer, Fanny Bouyer, Meritxell Donadeu, Tim Rowan, Grant Napier. GALVmed and DFID acknowledged.

Year: 2013

Subject Areas: Policy and Advocacy, Research and Development

Keywords: Disease Control, Trypanosomosis, Tsetse

Trypanosoma vivax GM6 Antigen: A Candidate Antigen for Diagnosis of African Animal Trypanosomosis in Cattle

Author: Pillay D, Izotte J, Fikru R, Buscher P, Mucache H, Neves L, Boulange A, Seck MT, Bouyer J, Napier GB, Chevtzoff C, Costou V, Baltz T

Year: 2013

Subject Areas: Research and Development

Keywords: Diagnosis, Trypanosomosis

Development and evaluation of an ITS1 “Touchdown” PCR forassessment of drug efficacy against animal African trypanosomosis

Author: Thao Tran, Grant Napier, Tim Rowan, Claudia Cordel, Michel Labuschagne, Vincent Delespaux, Nick Van Reet, Heidi Erasmus, Annesca Joubert, Philippe Büscher

Year: 2014

Subject Areas: Research and Development

Keywords: Diagnosis, Medical Trials, Trypanosomosis

Proteomic selection of immunodiagnostic antigens for Trypanosoma congolense.

Author: Jennifer R Fleming, Lalitha Sastry, Thomas W M Crozier, Grant B Napier, Lauren Sullivan, Michael A. J. Ferguson

Year: 2014

Subject Areas: Research and Development

Keywords: Diagnosis, Trypanosomosis