Comparative Sensitivity and Specificity of the 7SL sRNA Diagnostic Test for Animal Trypanosomiasis
Author: Contreras Garcia M, Walshe E, Steketee PC, Paxton E, Lopez-Vidal J, Pearce MC, Matthews KR, Ezzahra-Akki F, Evans A, Fairlie-Clark K, Matthews JB, Grey F, Morrison LJ
Year: 2022
Subject Areas: Research and Development
Keywords: Trypanosomiasis, diagnostic, sRNA, senistivity, specificity
Parasite specific 7SL-derived small RNA is an effective target for diagnosis of active trypanosomiasis infection
Author: Chiweshe SM, Steketee PC, Jayaraman S, Paxton E, Neophytou K, Erasmus H, Labuschagne M, Cooper A, MacLeod A, Grey FE, Morrison LJ
Year: 2019
Subject Areas: Research and Development
Keywords: 7SL, Diagnosis, RNA, Trypanosomiasis, parasite
The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing
Author: Daniela Begolo, Isabel M. Vincent,Federica Giordani,Ina Pöhner,Michael J. Witty,Timothy G. Rowan,Zakaria Bengaly,Kirsten Gillingwater,Yvonne Freund,Rebecca C. Wade,Michael P. Barrett,Christine Clayton
Year: 2018
Subject Areas: Research and Development
Keywords: AAT, African African Trypanosomosis, Benzoxaborole, Cattle, Protozoan, R&D, RNA, Resistance, Trypanosomiasis, Tryps ...plus 1 more
Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)
Author: Tsutomu Akama, Yong-Kang Zhang, Yvonne R. Freund, Pamela Berry, Joanne Lee, Eric E. Easom, Robert T. Jacobs, Jacob J. Plattner, Michael J. Witty, Rosemary Peter, Tim G. Rowan, Kirsten Gillingwater, Reto Brun, Bakela Nare, Luke Mercer, Musheng Xu, Jiangong Wang, Hao Liang
Year: 2017
Subject Areas: Research and Development
Keywords: AAT, African African Trypanosomosis, Benzoxaborole, Cattle, Lead optimisation, Protozoan, R&D, SAR, Trypanosomiasis, Trypanosomosis ...plus 2 more