Author: Zeinab Ammar, Nicolas Plazolles,Théo Baltz,Virginie Coustou. GALVmed and DFID acknowledged.
Year: 2013
About this Publication:
Understanding African Trypanosomiasis (AT) host-pathogen interaction is the key to an ‘‘anti-disease vaccine’’, a novel strategy to control AT. Here we provide a better insight into this poorly described interaction by characterizing the activation of a panel of endothelial cells by bloodstream forms of four African trypanosome species, known to interact with host endothelium. T. congolense, T. vivax, and T. b. gambiense activated the endothelial NF-kB pathway, but interestingly, not T. b. brucei. The parasitic TS (trans-sialidases) mediated this NF-kB activation, remarkably via their lectin-like domain and induced production of pro-inflammatory molecules not only in vitro but also in vivo, suggesting a considerable impact on pathogenesis. For the first time, TS activity was identified in T. b. gambiense BSF which distinguishes it from the subspecies T. b. brucei. The corresponding TS were characterized and shown to activate endothelial cells, suggesting that TS represent a common mediator of endothelium activation among trypanosome species with divergent physiopathologies. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium. Source: http://dx.plos.org/10.1371/journal.ppat.1003710 PLoS Pathog. 2013;9(10):e1003710. doi: 10.1371/journal.ppat.1003710. Epub 2013 Oct 10.
Grant: Tryps1
Subject Areas: Research and Development
Diseases: Trypanosomosis
Keywords:
Countries:
Angola, Benin, Cameroon, Central African Republic, China, Colombia, Congo, Democratic Republic Of, Costa Rica, Cote D'Ivoire, Egypt, El Salvador, Ethiopia, Ghana, Guinea-Bissau, India, Israel, Japan, Kenya, Malawi, Mozambique, Nepal, Niger, Senegal, Somalia, South Africa, Sudan, Tanzania, United Republic Of, Thailand, Togo, Zambia, Zimbabwe
