Author: Elizabeth Cook, George Russell, Dawn Grant, Christine Mutisya, Lazarus Omoto, Elizabeth Dobson, Felix Lankester, Vishvanath Nene
Year: 2019
About this Publication:
Wildebeest-associated malignant catarrhal fever (WA-MCF), a fatal disease of cattle caused by alcelaphine herpesvirus 1 (AlHV-1), is one of the most important seasonal diseases of cattle in wildebeest endemic areas, with annual incidence reaching 10%. Here we report efficacy of over 80% for a vaccine based on the attenuated AlHV-1 C500 strain, in preventing fatal WA-MCF in cattle exposed to natural wildebeest challenge. The study was conducted at Kapiti Plains Ranch Ltd, south-east of Nairobi, Kenya. Twenty-five cattle succumbed to WA-MCF; four of the remaining 71 cattle in the vaccine group (5.6%) and 21 of the remaining 72 control cattle (29.2%; ?2?=?13.6, df?=?1, p?
Grant: PLSHL2
Subject Areas: Research and Development
URL https://www.sciencedirect.com/science/article/pii/S0264410X19311041?via%3Dihub
Keywords:
Alcelaphine herpesvirus 1, MCF, Malignant catarrhal fever, Vaccine efficacy, Vaccine field trial, Wildebeest
Countries:
