Author: Pedro Ortiz, Susana Terrones, María Cabrera, Laura Ceballos, Laura Moreno,Candela Canton, Meritxell Donadeu, Carlos Lanusse, Luis Alvarez
Year: 2014
About this Publication:
Although oxfendazole (OFZ) is a well know broad-spectrum benzimidazole anthelmintic, the assessment of its potential trematodicidal activity remains unexplored. OFZ administration at single high doses has been recommended to control Taenia solium cysticercus in pigs. The current study investigated the flukicidal activity obtained after a single high (30mg/kg) oral dose of OFZ in pigs harbouring a natural Fasciola hepatica infection. Sixteen (16) local ecotype pigs were randomly allocated into two (2) experimental groups of 8 animals each named as follow: Untreated control and OFZ treated, in which animals received OFZ (Synanthic(®), Merial Ltd., 9.06% suspension) orally at 30mg/kg. At seven (7) days post-treatment, all the animals were sacrificed and direct adult liver fluke counts were performed following the WAAVP guidelines. None of the animals involved in this experiment showed any adverse event during the study. OFZ treatment as a single 30mg/kg oral dose showed a 100% efficacy against F. hepatica. In conclusion, the trial described here demonstrated an excellent OFZ activity against F. hepatica in naturally infected pigs, after its administration at a single oral dose of 30mg/kg.
Grant: PLSHL2
Subject Areas: Research and Development
Diseases: Porcine Cysticercosis
URL https://www.sciencedirect.com/science/article/pii/S0001706X14001077
Keywords:
Medical Trials, Pigs, Porcine Cysticercosis
Countries:
Angola, Benin, Bolivia, Bulgaria, Cameroon, Chile, China, Colombia, Congo, Republic Of, Ecuador, El Salvador, Guatemala, Madagascar, Malawi, Mozambique, Namibia, Nicaragua, Peru, Romania, Slovenia, South Africa, Spain, Togo
