Author: Alvarez L, Saumell C, Fusé L, Moreno L, Ceballos L, Domingue G, Donadeu M, Dungu B, Lanusse C.
Year: 2013
About this Publication:
The goal of the current experiment was to assess the clinical efficacy of oxfendazole (OFZ) administered as a single oral dose (30 mg/kg) to pigs naturally parasitized with Ascaris suum, Oesophagostomum spp., Metastrongylus spp. and Trichuris suis. Thirty-six local ecotype piglets were divided into three independent experiments, named I, II and III (n=12 each), respectively. Each experiment involved two different groups (n=6): Untreated Control and OFZ treated. Animals were naturally parasitized with A. suum (Experiments I, II and III), Oesophagostomum spp. (Experiments I and II), T. suis (Experiments II and III) and Metastrongylus spp. (Experiment I). Pigs in the treated group received OFZ (Synanthic(®), Merial Ltd., 9.06% suspension) orally at 30 mg/kg dose. At five (5) days post treatment, animals were sacrificed and the clinical efficacy of the OFZ treatment was established following the currently available WAAVP guidelines for a controlled efficacy test. None of the animals involved in this experiment showed any adverse events during the study. OFZ treatment given as a single 30 mg/kg oral dose showed a 100% efficacy against all the nematode parasites present in the three experiments. In conclusion, under the current experimental conditions, OFZ orally administered to naturally parasitized piglets at a single dose of 30 mg/kg was safe and highly efficacious (100%) against adult stages of A. suum, Oesophagostomum spp., T. suis and Metastrongylus spp.
Grant: PLSHL2
Subject Areas: Research and Development
Diseases: Porcine Cysticercosis
URL https://www.sciencedirect.com/science/article/pii/S0304401713000162
Keywords:
Medical Trials, Pigs, Porcine Cysticercosis
Countries:
Angola, Benin, Bolivia, Bulgaria, Cameroon, Chile, China, Colombia, Congo, Republic Of, Ecuador, El Salvador, Guatemala, Madagascar, Malawi, Mozambique, Namibia, Nicaragua, Peru, Romania, Slovenia, South Africa, Spain, Togo
