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Comparative Evaluation of Lumpy Skin Disease Virus-Based Live Attenuated Vaccines

Author: Andy Haegeman, Ilse De Leeuw, Laurent Mostin, Willem Van Campe, Laetitia Aerts, Estelle Venter, Eeva Tuppurainen, Claude Saegerman and Kris De Clercq

Year: 2021

About this Publication:

Vaccines form the cornerstone of any control, eradication and preventative strategy and this is no different for lumpy skin disease. However, the usefulness of a vaccine is determined by a multiplicity of factors which include stability, efficiency, safety and ease of use, to name a few. Although the vaccination campaign in the Balkans against lumpy skin disease virus (LSDV) was successful and has been implemented with success in the past in other countries, data of vaccine failure have also been reported. It was therefore the purpose of this study to compare five homologous live attenuated LSDV vaccines (LSDV LAV) in a standardized setting. All five LSDV LAVs studied were able to protect against a challenge with virulent LSDV. Aside from small differences in serological responses, important differences were seen in side effects such as a local reaction and a Neethling response upon vaccination between the analyzed vaccines. These observations can have important implications in the applicability in the field for some of these LSDV LAVs.

Grant: PLSHL2

Subject Areas: Research and Development

Diseases: Lumpy Skin Disease


Lumpy Skin Disease, live attenuated vaccines, lumpy skin disease vaccine, vaccine evaluation

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